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Strangles
Horses
Common Treatments
Health Problems
An infection of the upper respiratory tract caused by streptococcus equi equi bacteria. The infection is in the guttural pouches which are blind ended pockets within the horse’s head which communicate with the pharynx. It is a contagious disease which can be spread by direct and indirect contact with infected horses, i.e. nose to nose horse contact as well as being transferred by humans and fomites between horses. Horses can become silent carriers of the disease meaning that it can be very difficult to identify where the disease came from and keep a strict lid on an outbreak without in depth diagnostic tests.
Symptoms
An infected horse can demonstrate one or more of the following symptoms:
- Nasal discharge – yellow and thick, one or both nostrils.
- Cough.
- Breathing difficulties.
- High temperature (>38.5 C) – this may present as the horse being lethargic, not right and inappetant.
- Swelling under the chin.
- Abscesses burst from under chin or side of face.
- Difficulty eating and swallowing.
- Altered ‘voice’ – neigh sounds different.
- A ‘pyrexia of unknown origin’ – these are cases of poorly horses with a high temperature but the underlying cause is not immediately obvious (if early in disease before nasal discharge starts).
- No symptoms if a silent carrier.
Diagnosis
Identification of the bacteria itself confirms diagnosis. The most accurate way of doing this is via a PCR test which tests for the bacteria DNA. It can be difficult to culture the bacteria sometimes so a PCR is more often used as will have much less false negatives and it is much quicker (within 24 hours vs 3-7 days for culture).
The samples sent for PCR can be a nasopharyngeal wash, nasopharyngeal swab, pus from an abscess or guttural pouch wash. A nasopharyngeal wash is where sterile fluid is squirted up the horse’s nose to wash the nasal passages and pharynx and the returned fluid is captured in a bag to be sent off to the lab. This does not require any further equipment, can be done in the acute phase even if horses are quite sick and is inexpensive compared to the guttural pouch wash. It is also more accurate than a swab on comparison tests as it washes the whole area. A swab takes a sample of the nasal discharge from the nasal passage for analysis. A guttural pouch wash is more involved but is by far the most accurate test. It involves the horse being sedated, an endoscope camera being passed up the nasal passage and then into the guttural pouch itself, fluid is then washed into the pouch and then captured for sending to the lab. Because this washes the exact area where the infection starts it is the most accurate test but is more invasive and has higher cost associated with it.
Often on the day of presentation we would opt for a nasopharyngeal wash, and we can run strangles PCR tests ourselves in our on-site lab so results can be obtained within hours.
There is a blood test for strangles which measures antibodies (immune response). A one-off sample of this is often not very helpful but repeated blood tests 14 days apart can show an increasing immune response confirming active current exposure. The one-off sample which was positive could reflect current exposure or previous exposure which has left the horse with an immunity against strangles therefore is not helpful in identifying a currently affected horse.
Treatment
Treatment varies depending on the severity of the disease observed. All affected horses will need nursing with constant access to fresh water, wet feeds for easy swallowing and rest alongside biosecurity measures to reduce spread.
In mildly affected horses anti-inflammatories alone may be sufficient to control the fever and improve welfare whilst the immune system deals with the infection.
In moderately affected horses antibiotics may be indicated, the most appropriate choice being penicillin injections twice daily. These would be alongside anti-inflammatories.
In severely affected horses anti-inflammatories and penicillin may be combined with fluid therapy if the horse is not eating and drinking as well as active flushing of the infection from inside the guttural pouches via endoscopy. Sometimes indwelling catheters are placed and left in the pouches to allow daily flushing of the pouches. If the horse has abscesses bursting on the outside of the head then these need cleaning and caring for.
Biosecurity
A horse with strangles needs to be isolated away from other horses to minimise the risk of spread. This can be achieved in a stable or a small double fenced paddock where there is no ability for the horse to have direct contact with other horses or share a water source with other horses. When dealing with the affected horse you should wear overalls and gloves and scrub boots and hands afterwards. Strangles is not airborne and is an easy bacterium to kill, it requires direct spread of the snot itself to spread so with good hygiene it can be well contained with ease. It is sensible to restrict movement of horses on and off the yard as well to minimise spread and let all professionals know about the situation such as vets, EDTs, physios and farriers so they can either rearrange or use biosecurity measures.
Managing an outbreak
The best results are achieved when a yard works together in an outbreak. Firstly, a horse map should be drawn up to ascertain which other horses the affected horse could have possibly had contact with. A traffic light system can be useful – red = clinical signs, amber = potentially been in contact with infected horses but no signs yet, green = not been in contact with infected horses. Red horses will be isolated and treated, amber horses should be kept separate to green horses. All amber and green horses on the yard should have their noses checked for discharge and listened to for coughing and have their temperature taken twice daily and recorded in a book (tip – check green horses before amber). Any increase to over 38.5C or constant increasing each time should flag the horse as potentially early infected and prompt isolation (move from amber to red). This is the quickest way of stamping out the infection to isolate the horses before they start shedding via a snotty nose.
Confirming resolution
It is important to get a negative test result before ceasing biosecurity measures and stopping treatment. This is done with a guttural pouch wash and re-testing for strangles DNA via PCR. Approximately 1/3rd of horses infected with strangles will become a carrier of the disease. This happens by the disease outwardly looking like it has resolved but there is in fact some infection trapped in the guttural pouch which sits there dormant for up to many years. The immune system keeps it at bay and usually prevents obvious repeat infection in this horse, but the horse continues to be infectious to other horses intermittently.
Screening Tests
Due to the carrier status, it is sensible to screen horses prior to them moving onto a new yard or prior to purchase. The only way to do this accurately is the guttural pouch wash with PCR. Yards regularly request the blood test but this has been shown to be ineffective at identifying carrier horses so is difficult to recommend in this scenario.
Vaccination
There is a vaccination for strangles available, it is not a requirement and not routinely performed due to its short-lasting action although it is effective. Immunity is achieved 2 weeks after the second vaccination, which is 4 weeks after the first. Immunity lasts for 2 months after it is initiated. The main indication for its use would be in the event of an outbreak nearby, there being a lot of cases in the area or in advance of a known higher risk activity to provide as much prevention as is possible for that short period.